The legendary broadcaster revealed his wish in an exclusive interview with I Talk Telly which will be published in full on Sunday.
He was named after original host Eamonn Andrews, his 2008 autobiography was called This Is My Life and in an exclusive interview with I Talk Telly about the second series of Do The Right Thing on Channel 5, Eamonn Holmes OBE revealed the one thing he's yet to put on his TV CV.
When asked if there was anything left to achieve after a 38-year career in television, he said "I'd like to bring back This Is Your Life. I really think it has my name written all over it. It's a good example of old-fashioned TV and I was named after Eamonn Andrews, the best-known presenter of it."
He went on to add "I just sort of think, if you don't ask, you don't get. I think there's a reluctance in TV to do expensive programming. This Is Your Life would be an expensive programme, but I would genuinely like to do an iconic programme like that. Or even Who Wants to be a Millionaire? - those sort of programmes."
Originally hosted by Eamonn Andrews, This Is Your Life began in 1955 and ran for 48 years, with 18 series on BBC One and 25 on ITV. Following Eamonn's sad passing at the age of 64 in 1987, Michael Aspel took over as host until the series ended in 2003.
The show returned briefly in 2007 hosted by Sir Trevor McDonald for a one-off celebration of Simon Cowell, who had already been the subject of an episode in the final series of This Is Your Life in 2003.
The hugely popular show would see the host surprise a special guest, often at their place of work, and not always a celebrity, and present them with a big red book full of wonderful memories from their life. The guest will then be taken to the television studio, where sat in the audience were many family members, friends and work colleagues.
Over the years, some of the well-known faces to have been presented with that big red book have included; Dame Barbara Windsor, Sir Michael Parkinson, Dame Shirley Bassey, Richard and Judy, Frank Bruno MBE and the late Dame June Whitfield.
Eamonn did get a taste of what it would be like to host the show when he surprised his friend and colleague Gloria Hunniford OBE with the big red book on Loose Women, in a special episode celebrating her incredible 70 years in showbiz back in June 2017.
Back in March 2018, it was reported that Jonathan Ross was attached to a possible reboot of the iconic show, and the the show was being pitched to a number of TV channels. However, with no news yet about anyone picking up, it might not be too late for Eamonn's dreams to come true.
Do the Right Thing with Eamonn and Ruth returns Sunday at 9pm on Channel 5