The eight-part series is based on her acclaimed book of essays of the same name.
Survival of the Fittest will see Michelle Buteau play Mavis Beaumont, who's Black, plus-size and newly single.
She unexpectedly finds herself having to rebuild her life after putting all her eggs in one man's basket. But she's determined to not only survive but thrive with the support of her chosen family, a positive attitude, and a cute v-neck with some lip gloss.
Speaking about Survival of the Fittest, Michelle Buteau said "It's been so damn amazing finding a home with Netflix. To say I'm excited to continue my relationship with them is an understatement. I'm over the moon and I'm under it! Danielle has been a dream partner and I can't wait to share what we've been cooking up."
Netflix's Head of Comedy, Tracey Pakosta added "Michelle Buteau is many things: a brilliant writer, a gifted stand-up comedian and an empowering performer. But above all else: she is one of the funniest people alive. Paired with Danielle Sanchez-Witzel - one of TV's sharpest visionaries - Survival of the Thickest will bring Michelle's unique point of view to life."
Created by Michelle Buteau and Showrunner Danielle Sanchez-Witzel, Survival of the Fittest will be executive produced by Ravi Nandan and Alli Reich from A24.
The series continues Netflix's relationship with Buteau, who also has her own Netflix stand-up special, Michelle Buteau: Welcome to Buteaupia; hosts The Circle; narrates upcoming docuseries The Principles of Pleasure, will host the second season of Barbecue Showdown and starred in the feature film Always Be My Maybe, as well as the series Tales of the City.
Survival of the Thickest will air on Netflix